Labels:text | screenshot | black and white | black | font | document OCR: er the Effective androgen therapy requires eith y absorbed administration of testosterone in a slow form (dermal patches or micronised ora preparation) or the oral or parenteral nalogues, administration of chemically modified a d the rate Such chemical modifications either reta in effective of absorption or catabolismso as to sust potency of blood levels, or enhance the androgenic can be each molecule so that physiologic effects achieved at a lower blood level. useful Three types of modification have prove oxyl group; (Fig. 11.47): esterification of the 17ß-hydr fication of alkylation at the 170 position; and modi ons at the 2,the ring structure, particularly substitut 9 and 11 positions. Most drugs contain s and combinations of ring-structure alteration The either 17ct-alkylation or ester ...
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